At the Crux of Joint Crosstalk: TGFβ Signaling in the Synovial Joint
Abstract
The effect of the transforming growth factor beta (TGFβ) signaling pathway on joint homeostasis is tissue-specific, non-linear, and context-dependent, representing a unique complexity in targeting TGFβ signaling in joint disease. Here we discuss the variety of mechanisms that TGFβ signaling employs in the synovial joint to maintain healthy joint crosstalk and the ways in which aberrant TGFβ signaling can result in joint degeneration.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 02, 2022
- Source ID
- 10.1007/s11926-022-01074-6
Entities
People
- Karsyn N Bailey
- Tamara Alliston
Organizations
- National Institute of Dental and Craniofacial Research
- National Science Foundation
- United States Department of Defense