Nonparenchymal fluid is the source of increased mean diffusivity in preclinical Alzheimer's disease

Abstract

Although increased mean diffusivity of the white matter has been repeatedly linked to Alzheimer's disease pathology, the underlying mechanism is not known.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Apr 22, 2019
• Source ID: 10.1016/j.dadm.2019.03.002

Entities

People

• Arthur W. Toga
• Farshid Sepehrband
• Giuseppe Barisano
• Jeiran Choupan
• Meng Law
• Nasim Sheikh‐bahaei
• Ryan P. Cabeen
• The Alzheimer’s Disease Neuroimaging Initiative*

Organizations

• AbbVie
• Alfred Health
• Alzheimer's Association
• Alzheimer's Disease Neuroimaging Initiative
• Alzheimer's Drug Discovery Foundation
• BioClinica
• Biogen
• Bristol-Myers Squibb
• Canadian Institutes of Health Research
• Chiron Corporation
• Eli Lilly and Company
• GE HealthCare
• Hoffmann-La Roche
• Laboratoires Servier
• Lundbeck
• Merck & Co.
• National Institute of Biomedical Imaging and Bioengineering
• National Institute on Aging
• National Institutes of Health
• Pfizer
• Roche (United States)
• Takeda Pharmaceutical Company
• United States Department of Defense
• University of Southern California