Insufficient developmental excitatory neuronal activity fails to foster establishment of normal levels of inhibitory neuronal activity
Abstract
The nervous system is composed of excitatory and inhibitory neurons. One major class of inhibitory neurons release the neurotransmitter γ‐Aminobutyric acid (GABA). GABAergic inhibitory activity maintains the balance that is disrupted in conditions such as epilepsy. At least some GABAergic neurons are initially excitatory and undergo a developmental conversion to convert to inhibitory neurons. The mechanism(s) behind this conversion are thought to include a critical developmental increase in excitatory activity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 26, 2016
- Source ID
- 10.1016/j.ijdevneu.2016.09.009
Entities
People
- Edward Boumil
- Mary Guaraldi
- Mikaela Therrien
- Rishel Vohnoutka
- Sangmook Lee
- Thomas B. Shea
Organizations
- Army Research Office
- University of Massachusetts Lowell