Greater regional brain atrophy rate in healthy elderly subjects with a history of cigarette smoking
Abstract
Little is known about the effects of cigarette smoking on longitudinal brain morphological changes in the elderly. This study investigated the effects of a history of cigarette smoking on changes in regional brain volumes over 2 years in healthy, cognitively intact elderly individuals. We predicted that individuals with a history of cigarette smoking, compared with never smokers, demonstrate greater rate of atrophy over 2 years in regions that manifest morphological abnormalities in the early stages of Alzheimer's disease (AD), as well as in the extended brain reward/executive oversight system (BREOS), which is implicated in the development and maintenance of substance use disorders.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2012
- Source ID
- 10.1016/j.jalz.2011.10.006
Entities
People
- Michael W. Weiner
- Philip S Insel
- The Alzheimer Disease Neuroimaging Initiative
- Timothy C. Durazzo
Organizations
- Dana Foundation
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Aging
- National Institutes of Health
- Northern California Institute for Research and Education
- San Francisco VA Medical Center
- University of California
- University of California, San Francisco