Parkinsonism and distinct dementia patterns in a family with the MAPT R406W mutation

Abstract

The Arg406Trp (R406W) missense mutation in the microtubule‐associated protein‐tau gene (MAPT) is a known cause of early‐onset dementia. Various dementia phenotypes have been described, including frontotemporal dementia (FTD), FTD with parkinsonism, and early‐onset Alzheimer disease (EOAD)‐like presentations.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jun 03, 2013
Source ID
10.1016/j.jalz.2013.02.011

Entities

People

  • Adam C. Naj
  • Brian W. Kunkle
  • John R. Gilbert
  • Margaret A. Pericak‐vance
  • Martin A. Kohli
  • Regina M. Carney
  • Stephan Zuchner

Organizations

  • Alzheimer's Association
  • BrightFocus Foundation
  • United States Department of Defense
  • University of Miami

Tags

Fields of Study

  • Psychology

Readers

  • Aviation Science / Aeronautics.
  • Molecular Biology and Genetics
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.