Carriers of a common variant in the dopamine transporter gene have greater dementia risk, cognitive decline, and faster ventricular expansion

Abstract

Genetic variants in DAT1, the gene encoding the dopamine transporter (DAT) protein, have been implicated in many brain disorders. In a recent case‐control study of Alzheimer's disease (AD), a regulatory polymorphism in DAT1 showed a significant association with the clinical stages of dementia.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Dec 10, 2014
• Source ID: 10.1016/j.jalz.2014.10.011

Entities

People

• Boris A. Gutman
• Derrek P. Hibar
• Florence F. Roussotte
• Katherine L. Narr
• Paul M. Thompson
• Sarah K. Madsen
• The Alzheimer's Disease Neuroimaging Initiative (adni)

Organizations

• A.P. Giannini Foundation
• Alzheimer's Disease Neuroimaging Initiative
• National Institute of Biomedical Imaging and Bioengineering
• National Institute on Aging
• National Institutes of Health
• UCLA David Geffen School of Medicine
• University of Southern California

Tags

Fields of Study

• Psychology

Readers

• Molecular Biology and Genetics
• Prostate Cancer Biology.
• Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.

Technology Areas

• Biotechnology