The transitional association between β‐amyloid pathology and regional brain atrophy
Abstract
Alzheimer's disease (AD) is characterized by the accumulation of β‐amyloid (Aβ) associated with brain atrophy and cognitive decline. The functional form to model the association between Aβ and regional brain atrophy has not been well defined. To determine the relationship between Aβ and atrophy, we compared the performance of the usual dichotomization of cerebrospinal fluid (CSF) Aβ to identify subjects as Aβ+ and Aβ− with a trilinear spline model of CSF Aβ.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 09, 2014
- Source ID
- 10.1016/j.jalz.2014.11.002
Entities
People
- Clifford Jack
- John Q. Trojanowski
- Leslie M. Shaw
- Michael C. Donohue
- Michael W. Weiner
- Niklas Mattsson
- Paul S. Aisen
- Philip S Insel
- R. Scott Mackin
- The Alzheimer’s Disease Neuroimaging Initiative*
Organizations
- Alzheimer's Disease Neuroimaging Initiative
- Loma Linda University Medical Center
- Mayo Clinic
- Merck & Co.
- National Institute of Biomedical Imaging and Bioengineering
- National Institute of Mental Health
- National Institute on Aging
- National Institutes of Health
- Novartis
- Pfizer
- Sahlgrenska University Hospital
- Tohoku University
- University of California, San Diego
- University of California, San Francisco
- University of Pennsylvania