The Alzheimer's Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans

Abstract

We describe Alzheimer's Disease Neuroimaging Initiative (ADNI) Biomarker Core progress including: the Biobank; cerebrospinal fluid (CSF) amyloid beta (Aβ1–42), t‐tau, and p‐tau181 analytical performance, definition of Alzheimer's disease (AD) profile for plaque, and tangle burden detection and increased risk for progression to AD; AD disease heterogeneity; progress in standardization; and new studies using ADNI biofluids.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jul 01, 2015
Source ID
10.1016/j.jalz.2015.05.003

Entities

People

  • Andrew J. Saykin
  • Henrik Zetterberg
  • Holly Soares
  • Hugo Vanderstichele
  • John Q. Trojanowski
  • Jon B. Toledo
  • Ju‐hee Kang
  • Kaj Blennow
  • Leona Fields
  • Leslie M. Shaw
  • Magdalena Brylska
  • Magdalena Korecka
  • Michael W. Weiner
  • Michal J. Figurski
  • Nirali Shah
  • Paul S. Aisen
  • Robert A. Dean
  • Ronald C. Petersen
  • Teresa Waligorska
  • The Alzheimer’s Disease Neuroimaging Initiative*

Organizations

  • Alzheimer's Disease Neuroimaging Initiative
  • Bristol-Myers Squibb
  • Eli Lilly and Company
  • Indiana University
  • Indiana University School of Medicine
  • Inha University
  • Mayo Clinic
  • National Institute of Biomedical Imaging and Bioengineering
  • National Institute on Aging
  • National Institutes of Health
  • National Research Foundation
  • Sahlgrenska University Hospital
  • United States Department of Defense
  • United States Department of Veterans Affairs
  • University College London
  • University of California, San Diego
  • University of Pennsylvania

Tags

Fields of Study

  • Medicine

Readers

  • Defense Acquisition Program Management
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.