APOE ε4 carriers may undergo synaptic damage conferring risk of Alzheimer's disease

Abstract

Pathogenesis of Alzheimer's disease (AD) in apolipoprotein E ε4 (APOE ε4) carriers remains unclear. We hypothesize that APOE isoforms have differential effects on synaptic function.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jun 16, 2016
Source ID
10.1016/j.jalz.2016.05.003

Entities

People

  • Bonnie Levin
  • Chuanhui Dong
  • Clinton B. Wright
  • David Loewenstein
  • Elizabeth Crocco
  • Henrik Zetterberg
  • Kaj Blennow
  • The Alzheimer’s Disease Neuroimaging Initiative*
  • Xiaoyan Sun

Organizations

  • Alzheimer's Disease Neuroimaging Initiative
  • National Institute of Biomedical Imaging and Bioengineering
  • National Institute on Aging
  • National Institutes of Health
  • Sahlgrenska University Hospital
  • United States Department of Defense
  • University College London
  • University of Miami

Tags

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.