Metabolic network failures in Alzheimer's disease: A biochemical road map
Abstract
The Alzheimer's Disease Research Summits of 2012 and 2015 incorporated experts from academia, industry, and nonprofit organizations to develop new research directions to transform our understanding of Alzheimer's disease (AD) and propel the development of critically needed therapies. In response to their recommendations, big data at multiple levels are being generated and integrated to study network failures in disease. We used metabolomics as a global biochemical approach to identify peripheral metabolic changes in AD patients and correlate them to cerebrospinal fluid pathology markers, imaging features, and cognitive performance.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 21, 2017
- Source ID
- 10.1016/j.jalz.2017.01.020
Entities
People
- Alison Motsinger‐reif
- Amy C. Harms
- Andrew J. Saykin
- Ayse Demirkan
- Colette Blach
- Cornelia M. Van Duijn
- Cristina Legido‐quigley
- Daniel M. Rotroff
- Gabi Kastenmüller
- Gregory Louie
- Guido Dallmann
- Hongjie Zhu
- J. Will Thompson
- Jessica D. Tenenbaum
- John Q. Trojanowski
- John R. Jack
- Jon B. Toledo
- Joseph E. Lucas
- Karsten Suhre
- Kristaps Klavins
- Kuixi Zhu
- Kwangsik Nho
- Leslie M. Shaw
- Lisa St. John‐williams
- M. Arthur Moseley
- Madhav Thambisetty
- Marc Y.r. Henrion
- Matthias Arnold
- Michael W. Weiner
- P. Murali Doraiswamy
- Ramon Casanova
- Rebecca A. Baillie
- Rima Kaddurah‐daouk
- Rui Chang
- Shannon L. Risacher
- Shen Li
- Siamak Mahmoudiandehkordi
- Sudhir Varma
- Sungeun Kim
- Sven J. Van Der Lee
- Therese Koal
- Thomas Hankemeier
- Tyler Massaro
- Xianlin Han
Organizations
- Alzheimer's Association
- Duke University
- Helmholtz Zentrum München
- Houston Methodist Hospital
- Icahn School of Medicine at Mount Sinai
- Indiana University
- King's College London
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Aging
- National Institutes of Health
- North Carolina State University
- Sanford Burnham Prebys Medical Discovery Institute
- United States Department of Defense
- United States National Library of Medicine
- University of California, San Francisco
- University of Pennsylvania
- Weill Cornell Medicine