Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome
Abstract
Increasing evidence suggests a role for the gut microbiome in central nervous system disorders and a specific role for the gut‐brain axis in neurodegeneration. Bile acids (BAs), products of cholesterol metabolism and clearance, are produced in the liver and are further metabolized by gut bacteria. They have major regulatory and signaling functions and seem dysregulated in Alzheimer's disease (AD).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 15, 2018
- Source ID
- 10.1016/j.jalz.2018.07.217
Entities
People
- Alexandra Kueider‐paisley
- Alison Motsinger‐reif
- Andrew J. Saykin
- Colette Blach
- Cornelia M. Van Duijn
- Daniel M. Rotroff
- David A. Bennett
- For The Alzheimer's Disease Neuroimaging Initiative And The Alzheimer Disease Metabolomics Consortium
- Gabi Kastenmüller
- Gregory Louie
- Guoxiang Xie
- J. Will Thompson
- Jessica D. Tenenbaum
- John Jack
- John Q. Trojanowski
- Jon B. Toledo
- Kwangsik Nho
- Leslie M. Shaw
- Lisa St John Williams
- M. Arthur Moseley
- Matthias Arnold
- Michael W. Weiner
- Mitchel Allan Kling
- P. Murali Doraiswamy
- Philip L. De Jager
- Rebecca Baillie
- Rima Kaddurah‐daouk
- Sebastian Klein
- Shahzad Ahmad
- Shannon L. Risacher
- Siamak Mahmoudiandehkordi
- Simon Schafferer
- Sudeepa Bhattacharyya
- Therese Koal
- Thomas Hankemeier
- Wei Jia
- Xianlin Han
Organizations
- Columbia University
- Duke University
- Erasmus MC
- Erasmus University Rotterdam
- Helmholtz Zentrum München
- Houston Methodist Hospital
- Indiana University
- Leiden University
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Aging
- National Institutes of Health
- Netherlands Organisation for Health Research and Development
- North Carolina State University
- Shanghai Jiao Tong University
- United States National Library of Medicine
- University of Arkansas for Medical Sciences
- University of California, San Francisco
- University of Hawaiʻi System
- University of Pennsylvania
- University of Texas at Austin