C99 selectively accumulates in vulnerable neurons in Alzheimer's disease

Abstract

The levels and distribution of amyloid deposits in the brain does not correlate well with Alzheimer's disease (AD) progression. Therefore, it is likely that amyloid precursor protein and its proteolytic fragments other than amyloid b (Ab) contribute to the onset of AD.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jan 06, 2020
Source ID
10.1016/j.jalz.2019.09.002

Entities

People

  • Maria V. Pulina
  • Maya Hopkins
  • Paul Greengard
  • Vahram Haroutunian
  • Victor Bustos

Organizations

  • Cure Alzheimer's Fund
  • Fisher Center for Alzheimer's Research Foundation
  • Icahn School of Medicine at Mount Sinai
  • The Rockefeller University
  • United States Department of Defense

Tags

Fields of Study

  • Biology

Readers

  • Molecular and Cellular Biochemistry
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.