Zfra restores memory deficits in Alzheimer's disease triple‐transgenic mice by blocking aggregation of TRAPPC6AΔ, SH3GLB2, tau, and amyloid β, and inflammatory NF‐κB activation

Abstract

Zinc finger‐like protein that regulates apoptosis (Zfra) is a naturally occurring 31‐amino‐acid protein. Synthetic peptides Zfra1–31 and Zfra4–10 are known to effectively block the growth of many types of cancer cells.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Mar 06, 2017
• Source ID: 10.1016/j.trci.2017.02.001

Entities

People

• Chun‐i Sze
• Jean‐yun Chang
• Ming‐hui Lee
• Nan‐shan Chang
• Sing‐ru Lin
• Yao‐hsiang Shih
• Yu‐hao Lin
• Yu‐min Kuo

Organizations

• China Medical University
• Department of Health, Disability and Ageing
• National Cheng Kung University
• National Health Research Institutes
• National Science and Technology Council
• United States Department of Defense

Tags

Fields of Study

• Biology
• Chemistry

Readers

• Molecular Biology and Genetics
• Organizational Psychology.
• Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.