White matter hyperintensities in vascular contributions to cognitive impairment and dementia (VCID): Knowledge gaps and opportunities
Abstract
White matter hyperintensities (WMHs) are frequently seen on brain magnetic resonance imaging scans of older people. Usually interpreted clinically as a surrogate for cerebral small vessel disease, WMHs are associated with increased likelihood of cognitive impairment and dementia (including Alzheimer's disease [AD]). WMHs are also seen in cognitively healthy people. In this collaboration of academic, clinical, and pharmaceutical industry perspectives, we identify outstanding questions about WMHs and their relation to cognition, dementia, and AD. What molecular and cellular changes underlie WMHs? What are the neuropathological correlates of WMHs? To what extent are demyelination and inflammation present? Is it helpful to subdivide into periventricular and subcortical WMHs? What do WMHs signify in people diagnosed with AD? What are the risk factors for developing WMHs? What preventive and therapeutic strategies target WMHs? Answering these questions will improve prevention and treatment of WMHs and dementia.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2019
- Source ID
- 10.1016/j.trci.2019.02.001
Entities
People
- Adam M. Brickman
- Alex M. Helman
- Alifiya Kapasi
- Allyson C. Rosen
- Anders Wallin
- Angela L. Jefferson
- Anne Murray
- Aron M. Troen
- Athene Lee
- Atticus H Hainsworth
- Brandy L. Callahan
- Brittani R. Price
- C. Elizabeth Shaaban
- Cheryl Wellington
- D. Barton
- Deborah R. Gustafson
- Donna M. Wilcock
- Douglas L. Rosene
- Emanuele Brai
- Geert Jan Biessels
- Gene L. Bowman
- Hanneke F.m. Rhodius‐meester
- Heather M. Snyder
- Hee‐joon Bae
- Henrieta Scholtzova
- Isabelle Bos
- Jacqueline A. Rondeau
- Jay C. Kwon
- Jeremy D. Isaacs
- Jessica Alber
- Joanne M. Bell
- Julie A. Schneider
- Juraj Kukolja
- Kathleen M. Hayden
- Katie E. Osborn
- Laurel A. Beckett
- Melinda C. Power
- Narlon C.b.s. Silva
- Prashanthi Vemuri
- Rebecca F. Gottesman
- Roderick A. Corriveau
- Samuel N Lockhart
- Sandra E. Black
- Sara E. Berman
- Sharon Xiangwen Xie
- Silke Kern
- Silvia Fossati
- Sterling C. Johnson
- Susanne J. Van Veluw
- Suvarna Alladi
- Timothy M. Hughes
- Vladimir Hachinski
- Walter Swardfager
Organizations
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Boston University
- Brown University
- Canadian Institutes of Health Research
- Columbia University Vagelos College of Physicians and Surgeons
- Cure Alzheimer's Fund
- George Washington University
- Grossman School of Medicine
- Harvard Medical School
- Hebrew SeniorLife
- Hebrew University of Jerusalem
- Israel Science Foundation
- Johns Hopkins University
- Maastricht University
- Mayo Clinic
- Medical Research Council
- National Health and Medical Research Council
- National Institute of Mental Health and Neurosciences
- National Institute on Aging
- National Institutes of Health
- Our Lady of Fatima Hospital
- Sahlgrenska University Hospital
- Seoul National University
- St George's, University of London
- Stanford University
- State University of New York
- Syneos Health
- United States Department of Defense
- University Medical Center Utrecht
- University of British Columbia
- University of Calgary
- University of California, Davis
- University of Kentucky
- University of Melbourne
- University of Michigan School of Kinesiology
- University of Pennsylvania
- University of Pittsburgh
- University of Rhode Island
- University of Toronto
- University of Wisconsin–Madison
- Vanderbilt University
- Wake Forest School of Medicine
- Western University