The relative efficiency of time‐to‐progression and continuous measures of cognition in presymptomatic Alzheimer's disease
Abstract
Clinical trials on preclinical Alzheimer's disease are challenging because of the slow rate of disease progression. We use a simulation study to demonstrate that models of repeated cognitive assessments detect treatment effects more efficiently than models of time to progression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2019
- Source ID
- 10.1016/j.trci.2019.04.004
Entities
People
- Dan Li
- Michael C. Donohue
- Paul S. Aisen
- Samuel Iddi
- The Alzheimer’s Disease Neuroimaging Initiative*
- Wesley K. Thompson
Organizations
- Alzheimer's Disease Neuroimaging Initiative
- Canadian Institutes of Health Research
- National Institute of Biomedical Imaging and Bioengineering
- National Institute on Aging
- National Institutes of Health
- Statistics New Zealand
- United States Department of Defense
- University of California, San Diego
- University of Southern California