Reduced anhedonia following internet-based cognitive-behavioral therapy for depression is mediated by enhanced reward circuit activation
Abstract
Major depressive disorder (MDD) is a highly prevalent psychiatric condition, yet many patients do not receive adequate treatment. Novel and highly scalable interventions such as internet-based cognitive-behavioral-therapy (iCBT) may help to address this treatment gap. Anhedonia, a hallmark symptom of MDD that refers to diminished interest and ability to experience pleasure, has been associated with reduced reactivity in a neural reward circuit that includes medial prefrontal and striatal brain regions. Whether iCBT can reduce anhedonia severity in MDD patients, and whether these therapeutic effects are accompanied by enhanced reward circuit reactivity has yet to be examined.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 17, 2022
- Source ID
- 10.1017/s0033291722001106
Entities
People
- Christian A. Webb
- Diego A. Pizzagalli
- Elizabeth A Olson
- Isabelle M Rosso
- Roee Admon
- Scott L. Rauch
- Shir Hanuka
- William D. S. Killgore
Organizations
- Brain & Behavior Research Foundation
- Israel Science Foundation
- Tommy Fuss Fund