Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series

Document Details

Document Type
Pub Defense Publication
Publication Date
Apr 20, 2021
Source ID
10.1021/acs.jmedchem.1c00173

Entities

People

  • Aleksey Gerasyuto
  • Aloysus Lawong
  • Ann Huang
  • Anna Caroline Campos Aguiar
  • Benoît Laleu
  • David A. Fidock
  • David M. Shackleford
  • Dhelio B. Pereira
  • Diana R. Tomchick
  • Elizabeth Winzeler
  • Farah El Mazouni
  • Gong Chen
  • Goran Krilov
  • Ioanna Deni
  • Iñigo Angulo-Barturen
  • Jade Bath
  • Jaya Jayaseelan
  • Jeremy Burrows
  • Jessica Saunders
  • John A White
  • Josefine Striepen
  • Karen L. White
  • Kasiram Katneni
  • Kyra A. Schindler
  • Margaret A. Phillips
  • María Belén Jiménez-díaz
  • Michael J. Palmer
  • Nimisha Mittal
  • Patrick K. Tumwebaze
  • Philip J Rosenthal
  • Pradipsinh K. Rathod
  • Rafael V. C. Guido
  • Rahul Patil
  • Rajesh Chittimalla
  • Roland A. Cooper
  • Sachel Mok
  • Sergio Wittlin
  • Shatrughan P. Shahi
  • Shawn Watts
  • Sreekanth Kokkonda
  • Susan A. Charman
  • Tomas Yeo
  • Wen Wang
  • Xiaoyi Deng

Organizations

  • Columbia University
  • Dominican University of California
  • Gates Foundation
  • Infectious Diseases Research Collaboration
  • Medicines for Malaria Venture
  • Monash University
  • National Institute of Allergy and Infectious Diseases
  • Robert A. Welch Foundation
  • Schrödinger
  • Swiss Tropical and Public Health Institute
  • United States Department of Defense
  • University of Basel
  • University of California, San Diego
  • University of California, San Francisco
  • University of São Paulo
  • University of Texas Southwestern Medical Center
  • University of Texas at Austin
  • University of Washington