Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu7 Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962)

Document Details

Document Type
Pub Defense Publication
Publication Date
Jan 04, 2019
Source ID
10.1021/acs.jmedchem.8b01810

Entities

People

  • Alice L. Rodriguez
  • Anna L. Blobaum
  • Carson W. Reed
  • Colleen M. Niswender
  • Craig W. Lindsley
  • Darren W. Engers
  • Hanna F. Roenfanz
  • Jordan P. Washecheck
  • Marc C. Quitalig
  • Matthew T. Jenkins
  • P. Jeffrey Conn
  • Samantha E. Yohn
  • Vincent B. Luscombe

Organizations

  • United States Department of Defense
  • Vanderbilt University