Targeted Structure–Activity Analysis of Endochin-like Quinolones Reveals Potent Qi and Qo Site Inhibitors of Toxoplasma gondii and Plasmodium falciparum Cytochrome bc1 and Identifies ELQ-400 as a Remarkably Effective Compound against Acute Experimental Toxoplasmosis

Document Details

Document Type
Pub Defense Publication
Publication Date
Aug 17, 2018
Source ID
10.1021/acsinfecdis.8b00133

Entities

People

  • Aaron Nilsen
  • Alina Krollenbrock
  • Erin V. Mcconnell
  • Igor Bruzual
  • J Stone Doggett
  • Lev N. Zakharov
  • Martin J. Smilkstein
  • Michael K. Riscoe
  • Rolf Winter
  • Rozalia A Dodean
  • Sovitj Pou

Organizations

  • Biomedical Laboratory Research and Development, VA Office of Research and Development
  • Congressionally Directed Medical Research Programs
  • National Institute of Allergy and Infectious Diseases
  • Oregon Health & Science University
  • United States Department of Veterans Affairs
  • University of Oregon
  • VA Portland Health Care System