A mechanistic mathematical model of initiation and malignant transformation in sporadic vestibular schwannoma
Abstract
A vestibular schwannoma (VS) is a relatively rare, benign tumour of the eighth cranial nerve, often involving alterations to the gene NF2. Previous mathematical models of schwannoma incidence have not attempted to account for alterations in specific genes, and could not distinguish between nonsense mutations and loss of heterozygosity (LOH).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 12, 2022
- Source ID
- 10.1038/s41416-022-01955-8
Entities
People
- Chay Paterson
- Gareth Evans
- Ivana Bozic
- Miriam J Smith
- Xanthe Hoad
Organizations
- Congressionally Directed Medical Research Programs
- National Institute for Health and Care Research