A deadly dance: the choreography of host–pathogen interactions, as revealed by single-cell technologies
Abstract
Pathogens have numerous mechanisms by which they replicate within a host, who in turn responds by developing innate and adaptive immune countermeasures to limit disease. The advent of high-content single-cell technologies has facilitated a greater understanding of the properties of host cells harboring infection, the host’s pathogen-specific immune responses, and the mechanisms pathogens have evolved to escape host control. Here we review these advances and argue for greater inclusion of higher resolution single-cell technologies into approaches for defining immune evasion mechanisms by pathogens.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 06, 2018
- Source ID
- 10.1038/s41467-018-06214-0
Entities
People
- Diane L Bolton
- Mario Roederer
- Pratip K. Chattopadhyay
Organizations
- United States Department of Defense