Establishing the effects of mesoporous silica nanoparticle properties on in vivo disposition using imaging-based pharmacokinetics
Abstract
The progress of nanoparticle (NP)-based drug delivery has been hindered by an inability to establish structure-activity relationships in vivo. Here, using stable, monosized, radiolabeled, mesoporous silica nanoparticles (MSNs), we apply an integrated SPECT/CT imaging and mathematical modeling approach to understand the combined effects of MSN size, surface chemistry and routes of administration on biodistribution and clearance kinetics in healthy rats. We show that increased particle size from ~32- to ~142-nm results in a monotonic decrease in systemic bioavailability, irrespective of route of administration, with corresponding accumulation in liver and spleen. Cationic MSNs with surface exposed amines (PEI) have reduced circulation, compared to MSNs of identical size and charge but with shielded amines (QA), due to rapid sequestration into liver and spleen. However, QA show greater total excretion than PEI and their size-matched neutral counterparts (TMS). Overall, we provide important predictive functional correlations to support the rational design of nanomedicines.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 31, 2018
- Source ID
- 10.1038/s41467-018-06730-z
Entities
People
- Achraf Noureddine
- C. Jeffrey Brinker
- Elaine L. Bearer
- Eric N Coker
- Jonas G Croissant
- Kimberly S Butler
- Natalie L. Adolphi
- Paul N Durfee
- Prashant Dogra
- Vittorio Cristini
- Yu-shen Lin
- Zhihui Wang
Organizations
- Defense Threat Reduction Agency
- National Institutes of Health
- National Science Foundation
- United States Department of Energy
- University of Texas System