Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3
Abstract
How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Additionally, in humans, rejuvenation lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA synthesis. These results demonstrate a potent stimulus for RA synthesis by non-coding dsRNA, relevant to their broad functions in development and immunity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 26, 2019
- Source ID
- 10.1038/s41467-019-10811-y
Entities
People
- Amanda Nelson
- Ang Li
- Angela Park
- Anna Chien
- Benjamin Evans
- Dongwon Kim
- Eric M Wier
- Eugene Oh
- Gabriel Ghiaur
- Gaofeng Wang
- Ginette A. Okoye
- Jace W. Jones
- Jianshi Yu
- Lloyd S. Miller
- Luis A Garza
- Mary Sheu
- Maureen A. Kane
- Nashay Clemetson
- Nasif Islam
- Nathan K. Archer
- Noori Kim
- Ruosi Chen
- Sewon Kang
- Sooah Kim
- Vicky P. Prizmic
- Victoria Yu
- Weiliang Huang
- Wooyang Son
- Zhiqi Hu
- Zixiao Wang
Organizations
- National Institute of Arthritis and Musculoskeletal and Skin Diseases
- United States Department of Defense