Pre-clinical modeling of cutaneous melanoma
Abstract
Metastatic melanoma is challenging to manage. Although targeted- and immune therapies have extended survival, most patients experience therapy resistance. The adaptability of melanoma cells in nutrient- and therapeutically-challenged environments distinguishes melanoma as an ideal model for investigating therapy resistance. In this review, we discuss the current available repertoire of melanoma models including two- and three-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived xenograft. In particular, we highlight how each system recapitulates different features of melanoma adaptability and can be used to better understand melanoma development, progression and therapy resistance.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 05, 2020
- Source ID
- 10.1038/s41467-020-15546-9
Entities
People
- Meenhard Herlyn
- Rajasekharan Somasundaram
- Vito W. Rebecca
Organizations
- Adelson Foundation
- United States Department of Defense