All-printed stretchable corneal sensor on soft contact lenses for noninvasive and painless ocular electrodiagnosis
Abstract
Electroretinogram examinations serve as routine clinical procedures in ophthalmology for the diagnosis and management of many ocular diseases. However, the rigid form factor of current corneal sensors produces a mismatch with the soft, curvilinear, and exceptionally sensitive human cornea, which typically requires the use of topical anesthesia and a speculum for pain management and safety. Here we report a design of an all-printed stretchable corneal sensor built on commercially-available disposable soft contact lenses that can intimately and non-invasively interface with the corneal surface of human eyes. The corneal sensor is integrated with soft contact lenses via an electrochemical anchoring mechanism in a seamless manner that ensures its mechanical and chemical reliability. Thus, the resulting device enables the high-fidelity recording of full-field electroretinogram signals in human eyes without the need of topical anesthesia or a speculum. The device, superior to clinical standards in terms of signal quality and comfortability, is expected to address unmet clinical needs in the field of ocular electrodiagnosis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 09, 2021
- Source ID
- 10.1038/s41467-021-21916-8
Entities
People
- Baoxing Xu
- Bongjoong Kim
- Bryan W Boudouris
- Chi Hwan Lee
- Dawn Meyer
- Haozhe Zhang
- Heun Park
- Ho Joong Kim
- Kyunghun Kim
- Min Ku Kim
- Pete S Kollbaum
- Woo-Hyun Park
Organizations
- Air Force Office of Scientific Research
- Division of Civil, Mechanical & Manufacturing Innovation