Tumor suppressor p53 regulates intestinal type 2 immunity
Abstract
The role of p53 in tumor suppression has been extensively studied and well-established. However, the role of p53 in parasitic infections and the intestinal type 2 immunity is unclear. Here, we report that p53 is crucial for intestinal type 2 immunity in response to the infection of parasites, such asTritrichomonas murisandNippostrongylus brasiliensis. Mechanistically, p53 plays a critical role in the activation of the tuft cell-IL-25-type 2 innate lymphoid cell circuit, partly via transcriptional regulation of Lrmp in tuft cells. Lrmp modulates Ca2+influx and IL-25 release, which are critical triggers of type 2 innate lymphoid cell response. Our results thus reveal a previously unrecognized function of p53 in regulating intestinal type 2 immunity to protect against parasitic infections, highlighting the role of p53 as a guardian of immune integrity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 07, 2021
- Source ID
- 10.1038/s41467-021-23587-x
Entities
People
- Chun-Yuan Chang
- Fan Zhou
- Huaying Wang
- Jianming Wang
- John J Ponessa
- Juan Liu
- Juan M. Inclan-rico
- Lanjing Zhang
- Mark C. Siracusa
- Ping Xie
- Wenwei Hu
- Xue Yang
- Xuetian Yue
- Yuhan Zhao
- Zhaohui Feng
Organizations
- National Cancer Institute
- United States Department of Defense
- United States Department of Health and Human Services