Rapid custom prototyping of soft poroelastic biosensor for simultaneous epicardial recording and imaging
Abstract
The growing need for the implementation of stretchable biosensors in the body has driven rapid prototyping schemes through the direct ink writing of multidimensional functional architectures. Recent approaches employ biocompatible inks that are dispensable through an automated nozzle injection system. However, their application in medical practices remains challenged in reliable recording due to their viscoelastic nature that yields mechanical and electrical hysteresis under periodic large strains. Herein, we report sponge-like poroelastic silicone composites adaptable for high-precision direct writing of custom-designed stretchable biosensors, which are soft and insensitive to strains. Their unique structural properties yield a robust coupling to living tissues, enabling high-fidelity recording of spatiotemporal electrophysiological activity and real-time ultrasound imaging for visual feedback. In vivo evaluations of custom-fit biosensors in a murine acute myocardial infarction model demonstrate a potential clinical utility in the simultaneous intraoperative recording and imaging on the epicardium, which may guide definitive surgical treatments.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 17, 2021
- Source ID
- 10.1038/s41467-021-23959-3
Entities
People
- Abigail Durkes
- Arvin H. Soepriatna
- Bongjoong Kim
- Chi Hoon Park
- Chi Hwan Lee
- Craig J. Goergen
- Dong Rip Kim
- Haesoo Moon
- Hanmin Jang
- Hyowon Lee
- Jianchao Zhao
- Kwan Soo Lee
- Kyunghun Kim
- Nevin S. Gupta
- Woo-Hyun Park
- Yale Jeon
Organizations
- Air Force Office of Scientific Research
- Korea Institute for Advancement of Technology
- National Research Foundation of Korea
- National Science Foundation
- United States Department of Energy