Electro-optical mechanically flexible coaxial microprobes for minimally invasive interfacing with intrinsic neural circuits
Abstract
Central to advancing our understanding of neural circuits is developing minimally invasive, multi-modal interfaces capable of simultaneously recording and modulating neural activity. Recent devices have focused on matching the mechanical compliance of tissue to reduce inflammatory responses. However, reductions in the size of multi-modal interfaces are needed to further improve biocompatibility and long-term recording capabilities. Here a multi-modal coaxial microprobe design with a minimally invasive footprint (8–14 µm diameter over millimeter lengths) that enables efficient electrical and optical interrogation of neural networks is presented. In the brain, the probes allowed robust electrical measurement and optogenetic stimulation. Scalable fabrication strategies can be used with various electrical and optical materials, making the probes highly customizable to experimental requirements, including length, diameter, and mechanical properties. Given their negligible inflammatory response, these probes promise to enable a new generation of readily tunable multi-modal devices for long-term, minimally invasive interfacing with neural circuits.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 07, 2022
- Source ID
- 10.1038/s41467-022-30275-x
Entities
People
- Axel Nimmerjahn
- Conor Riley
- Donald Sirbuly
- Erin M. Carey
- Jenny Nguyen
- Sadik Esener
- Spencer Ward
Organizations
- National Institutes of Health
- National Science Foundation
- United States Department of Defense
- United States Department of Health and Human Services