Distinct organization of two cortico-cortical feedback pathways
Abstract
Neocortical feedback is critical for attention, prediction, and learning. To mechanically understand its function requires deciphering its cell-type wiring. Recent studies revealed that feedback between primary motor to primary somatosensory areas in mice is disinhibitory, targeting vasoactive intestinal peptide-expressing interneurons, in addition to pyramidal cells. It is unknown whether this circuit motif represents a general cortico-cortical feedback organizing principle. Here we show that in contrast to this wiring rule, feedback between higher-order lateromedial visual area to primary visual cortex preferentially activates somatostatin-expressing interneurons. Functionally, both feedback circuits temporally sharpen feed-forward excitation eliciting a transient increase–followed by a prolonged decrease–in pyramidal cell activity under sustained feed-forward input. However, under feed-forward transient input, the primary motor to primary somatosensory cortex feedback facilitates bursting while lateromedial area to primary visual cortex feedback increases time precision. Our findings argue for multiple cortico-cortical feedback motifs implementing different dynamic non-linear operations.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 27, 2022
- Source ID
- 10.1038/s41467-022-33883-9
Entities
People
- Andreas S Tolias
- Dmitry Kobak
- Fabian Sinz
- Federico Scala
- Jacob Reimer
- Jiakun Fu
- Na Zhou
- Paul G Fahey
- Shan Shen
- Xiaolong Jiang
- Zhenghuan Tan
Organizations
- Intelligence Advanced Research Projects Activity
- National Eye Institute
- National Institute of Mental Health
- United States Department of Health and Human Services