Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss
Abstract
This work rests on our non-viral tissue nanotransfection (TNT) platform to deliver MyoD (TNTMyoD) to injured tissue in vivo. TNTMyoD was performed on skin and successfully induced expression of myogenic factors. TNTMyoD was then used as a therapy 7 days following volumetric muscle loss (VML) of rat tibialis anterior and rescued muscle function. TNTMyoD is promising as VML intervention.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 20, 2022
- Source ID
- 10.1038/s41536-022-00259-y
Entities
People
- Amy Yoshiko Sato
- Andrew Clark
- Chandan K Sen
- Mohamed S El Masry
- Poornachander Reddy Guda
- Subhadip Ghatak
- Teresita Bellido
- Yi Xuan
Organizations
- United States Department of Defense