Gradients of neurotransmitter receptor expression in the macaque cortex
Abstract
Dynamics and functions of neural circuits depend on interactions mediated by receptors. Therefore, a comprehensive map of receptor organization across cortical regions is needed. In this study, we used in vitro receptor autoradiography to measure the density of 14 neurotransmitter receptor types in 109 areas of macaque cortex. We integrated the receptor data with anatomical, genetic and functional connectivity data into a common cortical space. We uncovered a principal gradient of receptor expression per neuron. This aligns with the cortical hierarchy from sensory cortex to higher cognitive areas. A second gradient, driven by serotonin 5-HT1Areceptors, peaks in the anterior cingulate, default mode and salience networks. We found a similar pattern of 5-HT1Aexpression in the human brain. Thus, the macaque may be a promising translational model of serotonergic processing and disorders. The receptor gradients may enable rapid, reliable information processing in sensory cortical areas and slow, flexible integration in higher cognitive areas.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 19, 2023
- Source ID
- 10.1038/s41593-023-01351-2
Entities
People
- Daniel S. Margulies
- Karl Zilles
- Ling Zhao
- Lucija Rapan
- Meiqi Niu
- Nicola Palomero-Gallagher
- Seán Froudist Walsh
- Ting Xu
- Xiao-Jing Wang