Honeycomb-shaped electro-neural interface enables cellular-scale pixels in subretinal prosthesis
Abstract
High-resolution visual prostheses require small, densely packed pixels, but limited penetration depth of the electric field formed by a planar electrode array constrains such miniaturization. We present a novel honeycomb configuration of an electrode array with vertically separated active and return electrodes designed to leverage migration of retinal cells into voids in the subretinal space. Insulating walls surrounding each pixel decouple the field penetration depth from the pixel width by aligning the electric field vertically, enabling a decrease of the pixel size down to cellular dimensions. We demonstrate that inner retinal cells migrate into the 25 μm deep honeycomb wells as narrow as 18 μm, resulting in more than half of these cells residing within the electrode cavities. Immune response to honeycombs is comparable to that with planar arrays. Modeled stimulation threshold current density with honeycombs does not increase substantially with reduced pixel size, unlike quadratic increase with planar arrays. This 3-D electrode configuration may enable functional restoration of central vision with acuity better than 20/100 for millions of patients suffering from age-related macular degeneration.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 23, 2019
- Source ID
- 10.1038/s41598-019-47082-y
Entities
People
- Daniel Palanker
- Elton Ho
- Keith Mathieson
- Ludwig Galambos
- Mohajeet Bhuckory
- Roopa Dalal
- Theodore I Kamins
- Thomas Anthony Flores
- Tiffany Huang
- Zhijie Charles Chen
Organizations
- National Institutes of Health
- Research to Prevent Blindness
- United States Department of Defense