Clinicopathological significance of endoplasmic reticulum stress proteins in ovarian carcinoma
Abstract
Epithelial ovarian cancer (EOC) is a leading cause of cancer-related mortality in the United States due to the late-stage disease at diagnosis. Overexpression of GRP78 and PDI following endoplasmic reticulum (ER) stress and activation of the unfolded protein response (UPR) promote growth and invasion in cancer. To identify novel prognostic biomarkers in EOC, here we determined the expression of ER stress-associated proteins (GRP78, ATF6 and PERK) and correlated with clinical outcome in EOC. Tissue microarray (TMA) samples from 415 tissues collected from three cancer centers (UM, USC, and KCCRI) were used to assess the expression levels of ER-associated proteins using immunohistochemistry (IHC). We observed that the expression levels of GRP78 (p p p p p = 0.03), while low expression of combined GRP78 and PDI correlated with better survival (p = 0.01) in high-grade serous. The increased expression of ER stress-associated proteins in EOC suggests a role for ER stress and the UPR in EOC. More importantly, our results demonstrate that GRP78 and PDI are potential biomarkers for EOC and could be used as dual prognostic markers.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 07, 2020
- Source ID
- 10.1038/s41598-020-59116-x
Entities
People
- Hisamori Kato
- Louis Dubeau
- Nouri Neamati
- Paulette Mhawech-fauceglia
- Rich Lieberman
- Ronald J. Buckanovich
- Shuzo Tamura
- Soma Samanta
- Yohei Miyagi
- Yvonne G. Lin
Organizations
- United States Army Medical Research and Development Command