Multi-modal nonlinear optical and thermal imaging platform for label-free characterization of biological tissue
Abstract
The ability to characterize the combined structural, functional, and thermal properties of biophysically dynamic samples is needed to address critical questions related to tissue structure, physiological dynamics, and disease progression. Towards this, we have developed an imaging platform that enables multiple nonlinear imaging modalities to be combined with thermal imaging on a common sample. Here we demonstrate label-free multimodal imaging of live cells, excised tissues, and live rodent brain models. While potential applications of this technology are wide-ranging, we expect it to be especially useful in addressing biomedical research questions aimed at the biomolecular and biophysical properties of tissue and their physiology.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 13, 2021
- Source ID
- 10.1038/s41598-021-86774-2
Entities
People
- Anita Mahadevan-Jansen
- Brian Mehl
- E Duco Jansen
- Eric Lieser
- Graham A. Throckmorton
- J. Logan Jenkins
- Jeff Brooker
- Jeremy B Ford
- Manqing Wang
- Rekha Gautam
- Shane Patton
- Wilson R. Adams
Organizations
- Air Force Office of Scientific Research
- American Society for Engineering Education