Towards precision radiation oncology: endocrine therapy response as a biomarker for personalization of breast radiotherapy
Abstract
Targeted therapies, such as endocrine therapies (ET), can exert selective pressure on cancer cells and promote adaptations that confer treatment resistance. In this study, we show that ET resistance in breast cancer drives radiation resistance through reprogramming of DNA repair pathways. We also show that pharmacological bromodomain and extraterminal domain inhibition reverses pathological DNA repair reprogramming in ET-resistant breast tumors and overcomes resistance to radiation therapy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 24, 2023
- Source ID
- 10.1038/s41698-023-00348-1
Entities
People
- Asal S. Rahimi
- Chantal Vidal
- Chika R. Nwachukwu
- D. Nathan Kim
- Guemhee Baek
- Kamal Pandey
- Prasanna Alluri
- Ram S Mani
- S. M. Nashir Udden
- Yulun Liu
Organizations
- Cancer Prevention and Research Institute of Texas
- National Institutes of Health
- United States Department of Defense