MMP9-sensitive polymers mediate environmentally-responsive bivalirudin release and thrombin inhibition
Abstract
Enzymatically-responsive bivalirudin polymers loaded in thermoresponsive hydrogels mediate localized therapeutic peptide delivery in spinal cord injuries. These materials respond to upregulated remodelling enzymes to release therapeutic peptide into injured tissue.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2015
- Source ID
- 10.1039/c4bm00259h
Entities
People
- A. E. Fischedick
- D. L. Sellers
- D. S. Chu
- M. J. Bocek
- P. J. Horner
- S. H. Pun
Organizations
- Congressionally Directed Medical Research Programs
- Craig H Neilsen Foundation
- National Institute of Neurological Disorders and Stroke
- United States Army
- University of Washington