Cross-strand histidine–aromatic interactions enhance acyl-transfer rates in beta-hairpin peptide catalysts

Abstract

A His–aryl interaction in a beta-hairpin catalyst provides rate enhancements of up to 18 000 for acyl transfer catalysis.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jan 01, 2014
Source ID
10.1039/c4ob01754d

Entities

People

  • M. L. Waters
  • M. Matsumoto
  • M. R. Gagné
  • Stephanie J. Lee

Organizations

  • Defense Threat Reduction Agency
  • National Academy of Sciences
  • Research Triangle Park
  • United States Army Research Laboratory
  • University of North Carolina at Chapel Hill
  • Yusuf Hamied Department of Chemistry

Tags

Fields of Study

  • Chemistry