Design of a microfluidic device to quantify dynamic intra-nuclear deformation during cell migration through confining environments
Abstract
Quantitative measurements of subcellular deformation in microfabricated environments provide an improved understanding of how cells overcome the resistance of the large and rigid nucleus during 3-D migration, with direct relevance to invasive cancer cells and immune cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2015
- Source ID
- 10.1039/c5ib00200a
Entities
People
- Celine Denais
- Jan Lammerding
- Josiah Sliz
- Patricia M Davidson
- Philipp Isermann
Organizations
- Air Force Civil Engineer Center
- Cornell University
- National Cancer Institute
- National Institutes of Health
- National Science Foundation Directorate for Biological Sciences
- United States Army
- Weill Institute for Cell and Molecular Biology