Fluorescent vinblastine probes for live cell imaging
Abstract
We describe the synthesis of several fluorescent analogues of the clinically approved microtubule destabilizing agent vinblastine. The evaluated probes are the most potent described and provides the first example of uptake, distribution and live cell imaging of this well known antimitotic agent.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2016
- Source ID
- 10.1039/c6cc04129a
Entities
People
- David B. Pirovich
- Hannes Mikula
- Jonathan C. Carlson
- Labros G. Meimetis
- Rainer H. Kohler
- Ralph Weissleder
- Randy J. Giedt
Organizations
- Center for Systems Biology
- Congressionally Directed Medical Research Programs
- Massachusetts General Hospital
- National Institute of Biomedical Imaging and Bioengineering
- United States Army