The small molecule JIB-04 disrupts O2binding in the Fe-dependent histone demethylase KDM4A/JMJD2A
Abstract
The pyridine hydrazone JIB-04, a specific inhibitor of Fe- and α-ketoglutarate-dependent, O2-activating histone lysine demethylases, is found to block the binding of O2in KDM4A through an O2-consumption assay, X-ray crystal structure data, and molecular modeling.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2017
- Source ID
- 10.1039/c6cc09882g
Entities
People
- Barbara Cascella
- Joseph M. Jez
- Liviu M Mirica
- Soon Goo Lee
- Sukrit Singh
Organizations
- National Institutes of Health
- United States Army
- United States Department of Defense
- Washington University in St. Louis
- Yusuf Hamied Department of Chemistry