Real-time imaging and quantitative analysis of doxorubicin transport in a perfusable microvessel platform
Abstract
The kinetics of solute transport across cell monolayers is complex, and often consists of multiple active transport processes in addition to passive diffusion. Here we demonstrate that mechanistic details of transport across biological barriers can be obtained from live cell imaging in a perfusable microvessel model with physiologically relevant geometry.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2016
- Source ID
- 10.1039/c6ib00082g
Entities
People
- Max I Bogorad
- Peter C. Searson
Organizations
- American Heart Association
- Defense Threat Reduction Agency
- Johns Hopkins University
- National Cancer Institute
- United States Army