Mass spectrometric directed system for the continuous-flow synthesis and purification of diphenhydramine
Abstract
An integrated system utilizing mass spectrometry for reaction screening, continuous-flow optimization, and continuous crystallization of diphenhydramine has been developed.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2017
- Source ID
- 10.1039/c7sc00905d
Entities
People
- Andy Koswara
- Bradley P. Loren
- David H. Thompson
- Kathryn Yammine
- Michael Wleklinski
- R. Graham Cooks
- Yanyang Hu
- Zoltan K Nagy
Organizations
- Defense Advanced Research Projects Agency
- Purdue University
- United States Army
- Yusuf Hamied Department of Chemistry