Approach control. Stereoelectronic origin of geometric constraints on N-to-S and N-to-O acyl shifts in peptides
Abstract
Intramolecular N-to-S or N-to-O acyl shifts in peptides are of fundamental and practical importance, as they constitute the first step in protein splicing and can be used for the synthesis of thioester-modified peptides required for native chemical ligation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2018
- Source ID
- 10.1039/c7sc04046f
Entities
People
- Charles L. Perrin
- Neal Devaraj
Organizations
- Army Research Office
- National Science Foundation
- United States Army
- Yusuf Hamied Department of Chemistry