Delivery of 5′-triphosphate RNA with endosomolytic nanoparticles potently activates RIG-I to improve cancer immunotherapy
Abstract
Delivery of a 5′ triphosphate RNA (3pRNA), a ligand for RIG-I, with endosomolytic nanoparticles (NP) augments response to anti-PD1 immune checkpoint blockade.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2019
- Source ID
- 10.1039/c8bm01064a
Entities
People
- John T Wilson
- Kyle W Becker
- Lihong Wang-bishop
- Max E. Jacobson
Organizations
- Alex's Lemonade Stand Foundation
- American Cancer Society
- Congressionally Directed Medical Research Programs
- United States Army
- Vanderbilt University