The efficiency of cytosolic drug delivery using pH-responsive endosomolytic polymers does not correlate with activation of the NLRP3 inflammasome
Abstract
Polymers that are unable to escape the early endosome, and instead cause lysosomal rupture, activate the NLRP3 inflammasome.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2019
- Source ID
- 10.1039/c8bm01643g
Entities
People
- Aamina Dandy
- Jessalyn J. Baljon
- John T Wilson
- Lihong Wang-bishop
- Max E. Jacobson
- Mohamed Wehbe
Organizations
- Congressionally Directed Medical Research Programs
- Division of Chemical, Bioengineering, Environmental, and Transport Systems
- Division of Materials Research
- National Institute of Allergy and Infectious Diseases
- Tuskegee University
- United States Army
- Vanderbilt University