Sterol A-ring plasticity in hedgehog protein cholesterolysis supports a primitive substrate selectivity mechanism
Abstract
The enzymatic agent of hedgehog protein cholesterolysis accommodates substrate sterols with undersized, oversized and distorted ring systems relative to cholesterol.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2019
- Source ID
- 10.1039/c8cc09729a
Entities
People
- Andrew G Wagner
- Brian Callahan
- Chunyu Wang
- Courtney L. Cooper
- Daniel A. Ciulla
- John L. Pezzullo
- José-Luis Giner
- Michael T. Jorgensen
- Nilesh K. Banavali
- Puja Goyal
- Xinyue Liu
Organizations
- Binghamton University
- National Cancer Institute
- Rensselaer Polytechnic Institute
- State University of New York College of Environmental Science and Forestry
- Syracuse University
- Troy University
- United States Army
- United States Department of Defense