Bridging the spatiotemporal scales of macromolecular transport in crowded biomimetic systems
Abstract
We combine single-molecule conformational tracking with digital Fourier microscopy to couple crowding-induced conformations and trajectories of single molecules with ensemble-averaged transport properties across an unprecedented spatiotemporal range to elucidate the complex dynamics of large DNA crowded by custom-designed networks of actin and microtubules.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2019
- Source ID
- 10.1039/c8sm02023j
Entities
People
- Devynn M Wulstein
- Hannah Rasmussen
- Kathryn E Regan
- Rae Robertson-Anderson
- Ryan McGorty
Organizations
- Air Force Office of Scientific Research
- American Chemical Society Petroleum Research Fund
- National Institute of General Medical Sciences
- United States Army
- University of San Diego