Visible photorelease of liquid biopsy markers following microfluidic affinity-enrichment

Abstract

We detail a heterobifunctional, 7-aminocoumarin photocleavable (PC) linker with unique properties to covalently attach Abs to surfaces and subsequently release them with visible light (400–450 nm).

Document Details

Document Type
Pub Defense Publication
Publication Date
Jan 01, 2020
Source ID
10.1039/c9cc09598e

Entities

People

  • Blake R. Peterson
  • Chamani Perera
  • Harshani Wijerathne
  • J. Matt Jackson
  • Malgorzata A. Witek
  • Rane Digamber
  • Richard S Givens
  • Steven A. Soper
  • Thilanga N. Pahattuge
  • Virginia Brown

Organizations

  • Lawrence University
  • National Cancer Institute
  • National Institute of Biomedical Imaging and Bioengineering
  • National Institute of General Medical Sciences
  • United States Army
  • United States Department of Defense
  • University of Kansas
  • Yusuf Hamied Department of Chemistry

Tags

Fields of Study

  • Chemistry

Readers

  • Chemistry (specifically Chemical Fluorescence)
  • Oncology and Biomarker-Based Cancer Detection.
  • Quantum Chemistry