BMP-2 delivery strategy modulates local bone regeneration and systemic immune responses to complex extremity trauma
Abstract
Bone nonunions remain compelling orthopedic challenges. Bone morphogenetic protein-2 (BMP-2) delivered in a heparin microparticle (HMP) delivery system improved local bone regeneration compared to BMP-2 delivered in the clinical standard collagen sponge.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2021
- Source ID
- 10.1039/d0bm01728k
Entities
People
- Albert Cheng
- Ayanna Prather
- Casey E. Vantucci
- George W. Woodruff
- Krishnendu Roy
- Laxminarayanan Krishan
- Robert E Guldberg
Organizations
- Armed Forces Institute of Regenerative Medicine
- Georgia Tech
- National Science Foundation
- Parker H. Petit Institute for Bioengineering & Bioscience
- United States Army
- University of Oregon
- Wallace H. Coulter Department of Biomedical Engineering