High pressure single-molecule FRET studies of the lysine riboswitch: cationic and osmolytic effects on pressure induced denaturation

Abstract

Protective mechanisms of the piezolyte trimethylamine N-oxide counteracting the pressure effects are revealed by single molecule studies at extreme pressures.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jan 01, 2020
Source ID
10.1039/d0cp01921f

Entities

People

  • David J. Nesbitt
  • Hsuan-lei Sung

Organizations

  • Air Force Office of Scientific Research
  • JILA
  • National Science Foundation
  • United States Army
  • University of Colorado
  • University of Colorado Boulder
  • Yusuf Hamied Department of Chemistry

Tags

Fields of Study

  • Chemistry

Readers

  • Analytical Chemistry
  • Molecular Genetics
  • Neurotoxicology